The E! News host was left devastated after fertility issues meant she struggled to go full-term with a pregnancy, and she miscarried a child in 2010.
Her battle to become a mum was hit with another setback last year (11) when she was diagnosed with breast cancer, which she beat after undergoing a successful double mastectomy.
But the star was ecstatic during an appearance on the Today show on Monday (23Apr12) when she announced she and husband Bill will welcome a child via a surrogate.
She added to E! News, ""We are so thrilled that our prayers have been answered. We are absolutely ecstatic to be sharing this with everyone who has been following our journey.""
The pair will be the tot's genetic parents.